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KMID : 1007520000090060346
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Food Science and Biotechnology
2000 Volume.9 No. 6 p.346 ~ p.352
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Effects of Rhodiola Extract Supplementation on Blood Lipid Concentration and Antioxidant Status in Rats Fed High - Fet or High Surcrose Diet
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Park, Ock Jin
Lee, Eun joo/Jang, Hae Dong
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Abstract
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To investigate the effect of Rhodiola rosea extract on blood lipid concentrations and anti-oxidative status of rats fed high-sucrose or high-fat diets, male Sprague-Dawley rats were divided into six groups and fed control, high-sucrose (56% weight basis) or high-fat (33% energy basis) diets supplemented with Rhodiola extract or no supplementations for four weeks. Body weight gain was not different among groups and supplementation with Rhodiola extract did not affect a body weight gain. However, feed efficiency ratio showed differences among groups. High-fat group had the highest feed efficiency ratio and control the lowest. Plasma triglyceride levels were lowered in high-fat and Rhodiola tract supplemented group. Whereas total cholesterol and HDL-cholesterol concentrations were not affected by Rhodiola extract supplementation. The antioxidant effect of dietary Rhodiola supplementation on the peroxidation potential of rats fed high-sucrose or high-fat diets were also examined in order to establish the relationship between physiological effects and antioxidant properties. The microsomal concentrations of thiobarbituric acid reative substance (TBARS) were not changed significantly by Rhodiola extract supplementation, but its supplementation increased the activities of antioxidative enzymes, copper-zinc superoxide dismutase (CuZn-SOD) and manganese superoxide dismutase (Mn-SOD) with high-sucrose diet. This demonstrates that Rhodiola extract has a potential to protect against hyperlipidemic conditions possibly through its antioxidative capacities.
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